Separation of enantiomers of chiral sulfoxides with methyl-and chloro-methyl-substitued tris-phenylcarbamate of cellulose as chiral selectors in high-performance liquid chromatography

Author: natia shashviashvili
Co-authors: mari-luiza konjaria
Keywords: chiral selector, chiral sulfoxide, mobile phase.
Annotation:

The goal of the present research was to screen newly synthesized chiral sulfoxides on their chiral recognition ability with 16 different cellulose phenylcarbamate-based chiral selectors in high-performance liquid chromatography. Most of these 16 chiral selectors were non-commercial products and synthesized in the frame of the present project. By systematic variation of the chemistry and structure of chiral selectors and selectands those structural features must be prevailed which are most critical for selector-selectand binding and chiral recognition ability. In this work only columns with chloro-substituted-phenylcarbamates are discussed. Our experiment was performed using high-performance liquid chromatograph (HPLC). We Following mobile phases were used: methanol, ethanol, 2-propanol and the mixture of n-hexane and 2-propanol.