Study of free radical processes in prostate tumor tisue

Author: Any Khazaradze
Keywords: Prostate tumors, antioxidants, free radicals
Annotation:

Prostate tumors are first among oncologic diseases in men. Prostate peripheral epithelium is characterized with a specific energetic metabolism, different from other hormone-dependent tumor cells. Malingnant transformation of prostate is followed by increase of Krebs cycle activity, which should result in an increased electron flow towards the mitochondrial respiratory chain. The goal of the given work was the study of antioxidant enzymes and free radical processes in tissue of men with prostate tumors. The studies have shown that in malignant prostate cancers the decrease of Fe-S cluster EPR-signal intensity (g=1.94, g=2.01) occurs parallel to the intensdification of free radiacl processes. Intensification of free radical processes and the accompanying damage of Fe-S clusters in malignant prostate cancer tissue indicate the disruption of respiratory chain complex I and II function. The study of glutathione-dependent antioxidant system revealed increased activity of the given system in adenocarcinoma, which provides the cancer cell with increased resistance to oxidative stress and to mitochondrial apoptosis. Decreased activity of superoxidedismutase and catalase accompanied by sharp intensification of lipid peroxidation point to decreased antioxidant status and protective function of the organism, as well as to progression of the disease.

Lecture files:

თავისუფალრადიკალური პროცესების შესწავლა პროსტატის სიმსივნურ ქსოვილში [ka]