Influence of Creatine on Antioxidant System in the Brain of Naturally Aggressive (Killer) and Non-Aggressive Animals

Author: Berika Beridze
Keywords: creatine, aggression, antioxidant system
Annotation:

Among the wide array of social behaviors displayed by organisms, undoubtedly one of the most important and well studied is aggression. Aggression is a highly complex behavior displayed by virtually all living organisms, and serves a wide range of adaptive functions. Despite its importance, aggression is a notoriously nebulous concept that has been defined and categorized in a multitude of ways over the years. In a recent years there’s widely investigated various food additives and among them creatine, and its influence on different biological systems. Creatine is mainly used by the persons with the high energy demand, such as sportsmen. There is some scientific data about induction of aggressive behavior in case of creatine supplementation, but still its’s not clear exact reason of such changes, so this part of the creatine influence is under investigation Is is known that creatine has antioxidant nature. Creatine displayed a significant ability to act as an antioxidant scavenger primarily against radical ions. It should be noted that creatine has direct antioxidant properties. From the abovementioned it could be clearly seen that the main goal of our research was to observe changes in rat brain antioxidant system in aggressive and non-aggressive individuals and also non-aggressive individuals supplemented by the creatine. It was investigated the level of aggressiveness in experimental animals by the physiological and biochemical approaches and enzymatic activities of some antioxidant enzymes’ (superoxide dismutase, catalase and etc). The enzymatic activities revealed some alterations in the antioxidant system.

Lecture files:

კრეატინის გავლენა ბუნებრივად აგრესიულ (მკვლელი) და არააგრესიული ცხოველების თავის ტვინის ანტიოქსიდანტურ სისტემაზე [ka]